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Diabetic neuropathy is one of sinequan pills complications of diabetes mellitus, detected in 30-50% of patients. Diabetic neuropathy is defined as the presence of signs of peripheral nerve damage in people with diabetes, with the exclusion of other causes of nervous system dysfunction. Diabetic neuropathy is characterized by a violation of nerve conduction, sensitivity, disorders of the somatic and / or autonomic nervous system. Due to the multiplicity of clinical manifestations, specialists in the field of endocrinology, neurology, gastroenterology, and podiatry have to deal with diabetic neuropathy.

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Diabetic neuropathy refers to metabolic polyneuropathies. A special role in the pathogenesis of diabetic neuropathy belongs to buy sinequan online - microangiopathies that disrupt the blood supply to the nerves. Multiple metabolic disorders that develop against this background ultimately lead to swelling of the nervous tissue, disruption of metabolic processes in nerve fibers, impaired conduction of nerve impulses, increased oxidative stress, development of autoimmune complexes and, ultimately, to atrophy of nerve fibers.

The risk factors for developing diabetic neuropathy are. Depending on the topography, peripheral neuropathy is distinguished, with predominant involvement of the spinal nerves in the pathological process, and autonomic neuropathy - in violation of the innervation of the internal organs. Diabetic neuropathy is isolated according to the syndromic classification. Syndrome of generalized symmetrical polyneuropathy.


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With a primary lesion of sensory nerves (sensory neuropathy) With a predominant lesion of the motor nerves (motor neuropathy) With a combined lesion of doxepin pills for sale and motor nerves (sensory motor neuropathy) Hyperglycemic neuropathy. Syndrome of autonomic (autonomous) diabetic neuropathy. Cardiovascular Gastrointestinal Urogenital Respiratory Sudomotor. Syndrome of focal or multifocal diabetic neuropathy. Cranial neuropathy Tunnel neuropathy Amyotrophy Radiculoneuropathy/plexopathy Chronic inflammatory demyelinating polyneuropathy (CIDP).

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A number of authors distinguishes central neuropathy and its following forms. diabetic encephalopathy (encephalomyelopathy), acute cerebrovascular disorders (PNMK, stroke), acute mental disorders caused by metabolic decompensation. According to the clinical classification, taking into account the manifestations of diabetic neuropathy, several stages of the process are distinguished.

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The stage of late complications (neuropathic foot deformity, diabetic foot, etc.). Insensitivity to thermal stimuli, hypersensitivity to buy doxepin online, even to very light touches, may develop. These symptoms tend to get worse at night. Diabetic neuropathy is accompanied by muscle weakness, weakening or loss of reflexes, which leads to a change in gait and impaired coordination of movements. Debilitating pain and paresthesia lead to insomnia, loss of appetite, weight loss, depression of the mental state of patients - depression.


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Late complications of peripheral diabetic neuropathy may include foot ulcers, hammer toe deformity, and collapse of the arch of the foot. Peripheral polyneuropathy often precedes the neuropathic form of diabetic foot syndrome. Autonomic diabetic neuropathy can develop and proceed in the form of cardiovascular, gastrointestinal, urogenital, sudomotor, respiratory and other forms, characterized by dysfunction of individual organs or entire systems.

The cardiovascular form of diabetic neuropathy can develop already in the first 3-5 years of doxepin. It is manifested by tachycardia at rest, orthostatic hypotension, ECG changes (prolongation of the QT interval), an increased risk of silent myocardial ischemia and infarction. Gastroenterological examination for diabetic neuropathy involves ultrasound of the abdominal organs, endoscopy, radiography of the stomach, studies of the passage of barium through the small intestine, tests for Helicobacter pylori.


For complaintsfrom the urinary system, a general urinalysis is examined, ultrasound of the kidneys, bladder (including ultrasound with the determination of residual urine), cystoscopy, intravenous urography, electromyography of the bladder muscles, etc. are performed. Treatment of diabetic neuropathy is carried out sequentially and in stages. Effective therapy of diabetic neuropathy is impossible without achieving compensation for diabetes mellitus. For this purpose, insulin or tableted antidiabetic drugs are prescribed, and glucose levels are monitored.


As part of an integrated approach to the treatment of diabetic neuropathy, it is necessary to develop an optimal diet and exercise regimen, reduce excess body weight, and maintain a normal level of blood pressure. During the main course, the intake of neurotropic vitamins (group B), antioxidants (alpha-lipoic acid, vitamin E), microelements (Mg and Zn preparations) is indicated. In the painful form of diabetic neuropathy, it is advisable to prescribe analgesics, anticonvulsants.


Early detection of diabetic neuropathy (both peripheral and autonomic) is the key to a favorable prognosis and improvement in the quality of life of patients. The initial stages of diabetic neuropathy can be reversible by achieving stable compensation of diabetes mellitus. Complicated diabetic neuropathy is a leading risk factor for painless myocardial infarction, cardiac arrhythmias, and non-traumatic amputations of the lower extremities.